Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …

Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …

With resistance to most antimalarials increasing, it is imperative that new drugs are
developed. We previously identified an aryl acetamide compound, MMV006833 (M-833) …

Zanzibar has made significant progress toward malaria elimination, but recent stagnation
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …

Background Recent cases of clinical failure in malaria patients in the United Kingdom (UK)
treated with artemether-lumefantrine have implications for malaria chemotherapy worldwide …

Antimicrobial resistance poses a significant threat to the sustainability of effective treatments
against the three most prevalent infectious diseases: malaria, human immunodeficiency …

Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …

Artemisinin-based combination therapies (ACTs) were introduced as the standard of care for
uncomplicated malaria in Africa almost two decades ago. Recent studies in East Africa have …