Cation− π interaction: Its role and relevance in chemistry, biology, and material science
Noncovalent interactions are essential for the existence of solid and liquid phases. 1, 2
Traditionally touted as weak forces, quantification of these interactions, which govern the …
Traditionally touted as weak forces, quantification of these interactions, which govern the …
[HTML][HTML] Tryptophan-and arginine-rich antimicrobial peptides: structures and mechanisms of action
Antimicrobial peptides encompass a number of different classes, including those that are
rich in a particular amino acid. An important subset are peptides rich in Arg and Trp …
rich in a particular amino acid. An important subset are peptides rich in Arg and Trp …
De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications
Antimicrobial peptides (AMPs) provide protection against a variety of pathogenic bacteria
and are, therefore, an important part of the innate immune system. Over the past decade …
and are, therefore, an important part of the innate immune system. Over the past decade …
Distribution of amino acids in a lipid bilayer from computer simulations
We have calculated the distribution in a lipid bilayer of small molecules mimicking 17 natural
amino acids in atomistic detail by molecular dynamics simulation. We considered both …
amino acids in atomistic detail by molecular dynamics simulation. We considered both …
Peptides and peptidomimetics for antimicrobial drug design
The purpose of this paper is to introduce and highlight a few classes of traditional
antimicrobial peptides with a focus on structure-activity relationship studies. After first …
antimicrobial peptides with a focus on structure-activity relationship studies. After first …
[HTML][HTML] The role of tryptophan side chains in membrane protein anchoring and hydrophobic mismatch
Tryptophan (Trp) is abundant in membrane proteins, preferentially residing near the lipid–
water interface where it is thought to play a significant anchoring role. Using a total of 3μs of …
water interface where it is thought to play a significant anchoring role. Using a total of 3μs of …
Physicochemical Features and Peculiarities of Interaction of AMP with the Membrane
Antimicrobial peptides (AMPs) are anti-infectives that have the potential to be used as a
novel and untapped class of biotherapeutics. Modes of action of antimicrobial peptides …
novel and untapped class of biotherapeutics. Modes of action of antimicrobial peptides …
Dual-mechanism glycolipidpeptide with high antimicrobial activity, immunomodulatory activity, and potential application for combined antibacterial therapy
M Niu, X Gu, J Yang, H Cui, X Hou, Y Ma, C Wang… - ACS …, 2023 - ACS Publications
Bacterial drug resistance is becoming increasingly serious, and it is urgent to develop
effective antibacterial drugs. Antimicrobial peptides (AMPs), as potential candidates against …
effective antibacterial drugs. Antimicrobial peptides (AMPs), as potential candidates against …
An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins
Phosphatidic acid (PA) is a minor but important phospholipid that, through specific
interactions with proteins, plays a central role in several key cellular processes. The simple …
interactions with proteins, plays a central role in several key cellular processes. The simple …
[HTML][HTML] Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria
BP100 is a short cationic antimicrobial peptide with a mechanism of action dependent on
peptide–lipid interactions and microbial surface charge neutralization. Although active …
peptide–lipid interactions and microbial surface charge neutralization. Although active …