Phaeochromocytoma (PC) and paraganglioma (PG) are neural crest cancers with high
heritability. Recent advances in molecular profiling, including multi-omics and single cell …

The complexity of omes–the key cellular ensembles (genome and epigenome,
transcriptome, proteome, and metabolome)–is becoming increasingly understood in terms of …

Context Sexual and ancestral differences in driver gene prevalence have been described in
many cancers but have not yet been investigated in pheochromocytoma and paraganglioma …

Over the past two decades, research into the genetic susceptibility behind
pheochromocytoma and paraganglioma (PPGL) has surged, ranking them among the most …

Graphical abstract Abstract The 5th edition of the World Health Organization (WHO)
classification of neuroendocrine neoplasms (NENs) is built to achieve a uniform terminology …

Vagal paraganglioma (VPGL) is a rare neuroendocrine tumor that originates from the
paraganglion associated with the vagus nerve. VPGLs present challenges in terms of …

Head and neck paragangliomas (HNPGLs) are rare neoplasms that, along with
pheochromocytomas and extra-adrenal paragangliomas, are associated with inherited …

Background Pheochromocytoma is one of the most hereditary human tumors with at least 20
susceptible genes undergoing germline and somatic mutations, and other mutations less …

Cutaneous hamartoneoplastic disorders encompass a wide variety of syndromes, among
which are Tuberous Sclerosis Complex (TSC), Nevoid Basal Cell Carcinoma syndrome …

Background Collectively, germline pathogenic variants in succinate dehydrogenase (SDH)
genes are the most common cause of hereditary paragangliomas. Loss of …