Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

Autophagy is a pivotal cytoprotective process that secures cellular homeostasis, fulfills
essential roles in development, immunity and defence against pathogens, and determines …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

During autophagosome formation in mammalian cells, isolation membranes (IMs;
autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER …

Phosphatidylinositol‐3‐phosphate (PI 3P) is a key player in membrane dynamics and
trafficking regulation. Most PI 3P is associated with endosomal membranes and with the …

In macropinocytosis, cells take up micrometre-sized droplets of medium into internal
vesicles. These vesicles are acidified and fused to lysosomes, their contents digested and …

Phosphoinositide signaling lipids (PIPs) are key regulators of membrane identity and
trafficking. Of these, PI (3, 5) P2 is one of the least well-understood, despite key roles in …

The double‐membrane‐bound autophagosome is formed by the closure of a structure
called the phagophore, origin of which is still unclear. The endoplasmic reticulum (ER) is …

The power of forward genetics in yeast is the foundation on which the field of autophagy
research firmly stands. Complementary work on autophagy in higher eukaryotes has …

Pancreatic cancer is a devastating disease with poor prognosis in the modern era.
Inflammatory processes have emerged as key mediators of pancreatic cancer development …