TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Summary p53 was discovered 45 years ago as an SV40 large T antigen binding protein,
coded by the most frequently mutated TP53 gene in human cancers. As a transcription …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron
accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous …

Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that
utilize oxidative phosphorylation as the main metabolic pathway to produce energy. Copper …

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Ferroptosis is an iron-driven cell death modality characterized by iron accumulation and
excessive lipid peroxidation. Ferroptosis is closely related to mitochondrial function, as …

Ferroptosis is a type of regulated cell death characterized by iron-mediated lipid
peroxidation, in contrast with apoptosis, autophagy, and necrosis. It can be triggered by …