A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

Acute physical activity leads to several changes in metabolic, cardiovascular, and immune
pathways. Although studies have examined selected changes in these pathways, the system …

Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that
is only partially understood. By using an integrated high-throughput transcriptional …

Meta-analysis of gene expression data sets is increasingly performed to help identify robust
molecular signatures and to gain insights into underlying biological processes. The …

The gastrointestinal microbiome is a complex ecosystem with functions that shape human
health. Studying the relationship between taxonomic alterations and functional …

Sex differences have been observed in acute coronavirus disease 2019 (COVID-19) and
Long Covid (LC) outcomes, with greater disease severity and mortality during acute infection …

Stomata are microscopic pores found on the surfaces of leaves that act to control CO2
uptake and water loss. By integrating information derived from endogenous signals with …

Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state.
Perturbations including uncontrolled hyperglycemia can drive β cells into more pliable states …

A complex organ contains a variety of cell types, each with its own distinct lineage and
function. Understanding the lineage and differentiation state of each cell is fundamentally …