Replication fork reversal and protection
S Qiu, G Jiang, L Cao, J Huang - Frontiers in cell and developmental …, 2021 - frontiersin.org
During genome replication, replication forks often encounter obstacles that impede their
progression. Arrested forks are unstable structures that can give rise to collapse and …
progression. Arrested forks are unstable structures that can give rise to collapse and …
Making choices: DNA replication fork recovery mechanisms
DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …
[HTML][HTML] CTCF and R-loops are boundaries of cohesin-mediated DNA loo**
Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
CRISPR-Cas9 is a powerful tool for genome editing, but the strict requirement for an NGG
protospacer-adjacent motif (PAM) sequence immediately next to the DNA target limits the …
protospacer-adjacent motif (PAM) sequence immediately next to the DNA target limits the …
FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics
C Stok, S Tsaridou, N van den Tempel, M Everts… - Cell reports, 2023 - cell.com
Joint DNA molecules are natural byproducts of DNA replication and repair. Persistent joint
molecules give rise to ultrafine DNA bridges (UFBs) in mitosis, compromising sister …
molecules give rise to ultrafine DNA bridges (UFBs) in mitosis, compromising sister …
How glutamate promotes liquid-liquid phase separation and DNA binding cooperativity of E. coli SSB protein
E. coli single-stranded-DNA binding protein (EcSSB) displays nearest-neighbor (NN) and
non-nearest-neighbor (NNN)) cooperativity in binding ssDNA during genome maintenance …
non-nearest-neighbor (NNN)) cooperativity in binding ssDNA during genome maintenance …
Polymerase theta-helicase promotes end joining by strip** single-stranded DNA-binding proteins and bridging DNA ends
Homologous recombination-deficient cancers rely on DNA polymerase Theta (Polθ)-
Mediated End Joining (TMEJ), an alternative double-strand break repair pathway. Polθ is …
Mediated End Joining (TMEJ), an alternative double-strand break repair pathway. Polθ is …
To join or not to join: decision points along the pathway to double-strand break repair vs. chromosome end protection
SM Ackerson, C Romney, PL Schuck… - Frontiers in cell and …, 2021 - frontiersin.org
The regulation of DNA double-strand breaks (DSBs) and telomeres are diametrically
opposed in the cell. DSBs are considered one of the most deleterious forms of DNA damage …
opposed in the cell. DSBs are considered one of the most deleterious forms of DNA damage …
[HTML][HTML] RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes
Homologous recombination (HR) plays an essential role in the repair of DNA double-strand
breaks (DSBs), replication stress responses, and genome maintenance. However …
breaks (DSBs), replication stress responses, and genome maintenance. However …
RADX controls RAD51 filament dynamics to regulate replication fork stability
The RAD51 recombinase forms nucleoprotein filaments to promote double-strand break
repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly …
repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly …