Obesity as a risk factor for dementia and Alzheimer's disease: the role of leptin
JA Flores-Cordero, A Pérez-Pérez… - International journal of …, 2022 - mdpi.com
Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
MicroRNA alteration, application as biomarkers, and therapeutic approaches in neurodegenerative diseases
MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various
neuronal and non-neuronal cell functions and play a key role in pathological conditions …
neuronal and non-neuronal cell functions and play a key role in pathological conditions …
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and …
The synthesis, characterization and biological evaluation of a series of novel N-substituted
phthalazine sulfonamide (5a-l) are disclosed. Phthalazines which are nitrogen-containing …
phthalazine sulfonamide (5a-l) are disclosed. Phthalazines which are nitrogen-containing …
Bioactive compounds and their derivatives: an insight into prospective phytotherapeutic approach against alzheimer's disease
Alzheimer's disease (AD) is a common neurodegenerative brain disorder that causes
cellular response alterations, such as impaired cholinergic mechanism, amyloid‐beta (Aβ) …
cellular response alterations, such as impaired cholinergic mechanism, amyloid‐beta (Aβ) …
Biphenyl-3-oxo-1, 2, 4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory
A series of novel piperazine tethered biphenyl-3-oxo-1, 2, 4-triazine derivatives were
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …
[HTML][HTML] Indole-3 carbinol and diindolylmethane mitigated β-amyloid-induced neurotoxicity and acetylcholinesterase enzyme activity: in silico, in vitro, and network …
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
Investigation of novel benzoxazole-oxadiazole derivatives as effective anti-Alzheimer's agents: in vitro and in silico approaches
Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …
by cognitive and memory decline and adversely affects the people of old age. The …
Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for …
Our present work demonstrates the successful design and synthesis of a new class of
compounds based upon a multitargeted directed ligand design approach to discover new …
compounds based upon a multitargeted directed ligand design approach to discover new …