The proliferation of four-dimensional imaging technologies, increasing computational
speeds, improved simulation algorithms, and the widespread availability of powerful …

As the pulsatile cardiac blood flow drives the heart valve leaflets to open and close, the flow
in the vicinity of the valve resembles a pulsed jet through a nonaxisymmetric orifice with a …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …

Successful mitral valve repair is dependent upon a full understanding of normal and
abnormal mitral valve anatomy and function. Computational analysis is one such method …

The leaflets of the mitral valve interact with the mitral jet and significantly impact diastolic
flow patterns, but the effect of mitral valve morphology and kinematics on diastolic flow and …

A set of multiscale simulations has been created to examine the dynamic behavior of the
human aortic valve (AV) at the cell, tissue, and organ length scales. Each model is fully three …

Understanding the interaction between the valves and walls of the heart is important in
assessing and subsequently treating heart dysfunction. This study presents an integrated …

Patients with bicuspid aortic valve (BAV) are more likely to develop a calcific aortic stenosis
(CAS), as well as a number of other ailments, as compared to their cohorts with normal …

In the current scientific literature, particular attention is dedicated to the study of the mitral
valve and to comprehension of the mechanisms that lead to its normal function, as well as …

A new flow-structure interaction method is presented, which couples a sharp-interface
immersed boundary method flow solver with a finite-element method based solid dynamics …