In this article we consider the mechanisms by which the calcium-sensing receptor (CaSR)
induces its cellular responses via the control (activation or inhibition) of signaling pathways …

The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a
pivotal role in maintaining body water balance. The channel is regulated by the peptide …

The ability to monitor changes in the ionic composition of the extracellular environment is a
crucial feature that has evolved in all living organisms. The cloning and characterization of …

Abstract Background Aquaporins (AQPs) are a family of proteins that can act as water
channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body …

Under physiological conditions, excessive loss of water through the urine is prevented by
the release of the antidiuretic hormone arginine-vasopressin (AVP) from the posterior …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-
protein coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone …

The pathophysiology of urinary stone formation is complex, involving a combination of
metabolic, genetic, and environmental factors. Over the past decades, remarkable advances …

Renal collecting duct principal cells play a key role in controlling body water balance.
Principal cells express the water channels AQP2, AQP3, and AQP4 that mediate renal water …