The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …

The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …

Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Fibrosis—excessive scarring after injury—causes> 40% of disease-related deaths
worldwide. In this misguided repair process, activated fibroblasts drive the destruction of …

Endothelial barrier function is an essential and tightly regulated process that ensures proper
compartmentalization of the vascular and interstitial space, while allowing for the diffusive …

Pulmonary epithelial barrier dysfunction is a critical pathophysiological process in
pneumonia and associated invasive infections, such as those caused by Acinetobacter …