Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies
P Würtz, AJ Kangas, P Soininen… - American journal of …, 2017 - academic.oup.com
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
Mendelian randomization for studying the effects of perturbing drug targets
D Gill, MK Georgakis, VM Walker… - Wellcome open …, 2021 - pmc.ncbi.nlm.nih.gov
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to
be approved after clinical development. In this paper, we provide an overview of how natural …
be approved after clinical development. In this paper, we provide an overview of how natural …
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
Genome-wide characterization of circulating metabolic biomarkers
MK Karjalainen, S Karthikeyan, C Oliver-Williams… - Nature, 2024 - nature.com
Genome-wide association analyses using high-throughput metabolomics platforms have led
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
U Võsa, A Claringbould, HJ Westra, MJ Bonder… - Nature …, 2021 - nature.com
Trait-associated genetic variants affect complex phenotypes primarily via regulatory
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …
The MRC IEU OpenGWAS data infrastructure
B Elsworth, M Lyon, T Alexander, Y Liu, P Matthews… - BioRxiv, 2020 - biorxiv.org
Data generated by genome-wide association studies (GWAS) are growing fast with the
linkage of biobank samples to health records, and expanding capture of high-dimensional …
linkage of biobank samples to health records, and expanding capture of high-dimensional …
Rare and common genetic determinants of metabolic individuality and their effects on human health
P Surendran, ID Stewart, VPW Au Yeung, M Pietzner… - Nature Medicine, 2022 - nature.com
Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …
molecular origins of human diseases. Untargeted high-throughput metabolomic …
The GTEx Consortium atlas of genetic regulatory effects across human tissues
GTEx Consortium - Science, 2020 - science.org
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …
effects on the transcriptome across human tissues and to link these regulatory mechanisms …
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: a multivariable Mendelian randomisation …
TG Richardson, E Sanderson, TM Palmer… - PLoS …, 2020 - journals.plos.org
Background Circulating lipoprotein lipids cause coronary heart disease (CHD). However,
the precise way in which one or more lipoprotein lipid-related entities account for this …
the precise way in which one or more lipoprotein lipid-related entities account for this …
Genetics of 35 blood and urine biomarkers in the UK Biobank
N Sinnott-Armstrong, Y Tanigawa, D Amar, N Mars… - Nature …, 2021 - nature.com
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …