Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …

Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

The entropic brain hypothesis proposes that within upper and lower limits, after which
consciousness may be lost, the entropy of spontaneous brain activity indexes the …

Responses to psychedelics are notoriously difficult to predict, yet significant work is currently
underway to assess their therapeutic potential and the level of interest in psychedelics …

The classical psychedelic drugs, including psilocybin, lysergic acid diethylamide and
mescaline, were used extensively in psychiatry before they were placed in Schedule I of the …

A core aspect of the human self is the attribution of personal relevance to everyday stimuli
enabling us to experience our environment as meaningful [1]. However, abnormalities in the …

Studying transitions in and out of the altered state of consciousness caused by intravenous
(IV) N, N-Dimethyltryptamine (DMT-a fast-acting tryptamine psychedelic) offers a safe and …