Unique mutations in SARS-CoV-2 Omicron subvariants' non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion
A Hossain, S Akter, AA Rashid, S Khair… - Microbial …, 2022 - Elsevier
SARS-CoV-2 is the causative agent behind the ongoing COVID-19 pandemic. This virus is a
cumulative outcome of mutations, leading to frequent emergence of new variants and their …
cumulative outcome of mutations, leading to frequent emergence of new variants and their …
SARS-CoV-2 ORF8: a rapidly evolving immune and viral modulator in COVID-19
A Arduini, F Laprise, C Liang - Viruses, 2023 - mdpi.com
The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three
years, and the frequent emergence of variants continues to strain global health. Although …
years, and the frequent emergence of variants continues to strain global health. Although …
Fitness effects of mutations to SARS-CoV-2 proteins
Abstract Knowledge of the fitness effects of mutations to SARS-CoV-2 can inform
assessment of new variants, design of therapeutics resistant to escape, and understanding …
assessment of new variants, design of therapeutics resistant to escape, and understanding …
Multiple mutations of SARS-CoV-2 Omicron BA. 2 variant orchestrate its virological characteristics
Previous studies on the Omicron BA. 2 variant suggested that the virological characteristics
of BA. 2 are determined by the mutations in at least two different regions of the viral genome …
of BA. 2 are determined by the mutations in at least two different regions of the viral genome …
SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity
Circulating bat coronaviruses represent a pandemic threat. However, our understanding of
bat coronavirus pathogenesis and transmission potential is limited by the lack of …
bat coronavirus pathogenesis and transmission potential is limited by the lack of …
SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths, posing a substantial threat to global public health. Viruses evolve different strategies …
deaths, posing a substantial threat to global public health. Viruses evolve different strategies …
SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causes injury to
multiple organ systems, including the brain. SARS‐CoV‐2's neuropathological mechanisms …
multiple organ systems, including the brain. SARS‐CoV‐2's neuropathological mechanisms …
Ghosts of the past: Elemental composition, biosynthesis reactions and thermodynamic properties of Zeta P. 2, Eta B. 1.525, Theta P. 3, Kappa B. 1.617. 1, Iota B. 1.526 …
From the perspectives of molecular biology, genetics and biothermodynamics, SARS-CoV-2
is the among the best characterized viruses. Research on SARS-CoV-2 has shed a new …
is the among the best characterized viruses. Research on SARS-CoV-2 has shed a new …
Virological characteristics correlating with SARS-CoV-2 spike protein fusogenicity
Introduction The severe acute respiratory syndrome coronavirus (SARS-CoV-2) spike (S)
protein is essential in mediating membrane fusion of the virus with the target cells. Several …
protein is essential in mediating membrane fusion of the virus with the target cells. Several …
MasitinibL shows promise as a drug-like analog of masitinib that elicits comparable SARS-Cov-2 3CLpro inhibition with low kinase preference
SARS-CoV-2 infection has led to several million deaths worldwide and ravaged the
economies of many countries. Hence, develo** therapeutics against SARS-CoV-2 …
economies of many countries. Hence, develo** therapeutics against SARS-CoV-2 …