Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

High Density Lipoprotein (HDL) particles, beyond serving as lipid transporters and playing a
key role in reverse cholesterol transport, carry a highly variable number of proteins, micro …

HDL cholesterol activates endothelial cell production of the atheroprotective signaling
molecule NO, and it promotes endothelial repair. In this issue of the JCI, Besler et al. provide …

In addition to its role in reverse cholesterol transport, high-density lipoprotein (HDL)
cholesterol has direct action on numerous cell types that influence cardiovascular and …

Prospective population studies in the primary prevention setting have shown that reduced
plasma levels of HDL cholesterol are associated with an increased risk of coronary disease …

Alterations affecting high-density lipoproteins (HDLs) are one of the various abnormalities
observed in dyslipidemia in type 2 diabetes mellitus (T2DM) and obesity. Kinetic studies …

Atherosclerotic diseases are responsible for a significant part of morbidity and mortality in
western countries. According to the classical views, atherosclerotic lesions develop as the …

Vascular endothelial dysfunction is determined by both genetic and environmental factors
that cause decreased bioavailability of the vasodilator nitric oxide. This is a hallmark of …

It is well recognised that increased levels of high density lipoprotein (HDL) protect against
atherosclerosis and correlate with improved prognosis for vascular disease associated …

Ambient and indoor air pollution contributes annually to approximately seven million
premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In …