A review on advancements in feature selection and feature extraction for high-dimensional NGS data analysis

K Borah, HS Das, S Seth, K Mallick, Z Rahaman… - Functional & Integrative …, 2024 - Springer
Recent advancements in biomedical technologies and the proliferation of high-dimensional
Next Generation Sequencing (NGS) datasets have led to significant growth in the bulk and …

Predicting heart cell types by using transcriptome profiles and a machine learning method

S Ding, D Wang, X Zhou, L Chen, K Feng, X Xu… - Life, 2022 - mdpi.com
The heart is an essential organ in the human body. It contains various types of cells, such as
cardiomyocytes, mesothelial cells, endothelial cells, and fibroblasts. The interactions …

Predicting RNA 5‐Methylcytosine Sites by Using Essential Sequence Features and Distributions

L Chen, ZD Li, SQ Zhang, YH Zhang… - BioMed Research …, 2022 - Wiley Online Library
Methylation is one of the most common and considerable modifications in biological systems
mediated by multiple enzymes. Recent studies have shown that methylation has been …

Chlorine disinfectants promote microbial resistance in Pseudomonas sp.

C Tong, H Hu, G Chen, Z Li, A Li, J Zhang - Environmental Research, 2021 - Elsevier
The substantial use of disinfectants has increased antibiotic resistance, thereby mediating
serious ecological safety issues worldwide. Accumulating studies have reported the role of …

Infectious uveitis: a comprehensive systematic review of emerging trends and molecular pathogenesis using network analysis

MA Asghar, S Tang, LP Wong, P Yang… - Journal of Ophthalmic …, 2024 - Springer
Background Infectious uveitis is a significant cause of visual impairment worldwide, caused
by diverse pathogens such as viruses, bacteria, fungi, and parasites. Understanding its …

iMPT‐FDNPL: Identification of Membrane Protein Types with Functional Domains and a Natural Language Processing Approach

W Chen, L Chen, Q Dai - Computational and Mathematical …, 2021 - Wiley Online Library
Membrane protein is an important kind of proteins. It plays essential roles in several cellular
processes. Based on the intramolecular arrangements and positions in a cell, membrane …

RFhy-m2G: identification of RNA N2-methylguanosine modification sites based on random forest and hybrid features

C Ao, Q Zou, L Yu - Methods, 2022 - Elsevier
N2-methylguanosine is a post-transcriptional modification of RNA that is found in eukaryotes
and archaea. The biological function of m2G modification discovered so far is to control and …

Similarity‐Based Method with Multiple‐Feature Sampling for Predicting Drug Side Effects

Z Wu, L Chen - Computational and mathematical methods in …, 2022 - Wiley Online Library
Drugs can treat different diseases but also bring side effects. Undetected and unaccepted
side effects for approved drugs can greatly harm the human body and bring huge risks for …

Kaempferol-3-O-rutinoside, a flavone derived from Tetrastigma hemsleyanum, suppresses lung adenocarcinoma via the calcium signaling pathway

Y Li, X Yu, Y Wang, X Zheng, Q Chu - Food & Function, 2021 - pubs.rsc.org
Lung cancer has been threatening human health worldwide for a long time. However, the
clinic therapies remain unsatisfactory. In this study, the anti-adenocarcinoma lung cancer …

Identification of cell markers and their expression patterns in skin based on single-cell RNA-sequencing profiles

X Zhou, S Ding, D Wang, L Chen, K Feng, T Huang… - Life, 2022 - mdpi.com
Atopic dermatitis and psoriasis are members of a family of inflammatory skin disorders.
Cellular immune responses in skin tissues contribute to the development of these diseases …