THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

In recent years, obesity and its associated health disorders and costs have increased.
Accumulation of adipose tissue, or fat, in the intra-abdominal adipose depot is associated …

We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative
precursor of a pair of peptides that share substantial amino acid identities with the gut …

The novel neuropeptides called hypocretins (orexins) have recently been identified as being
localized exclusively in cell bodies in a subregion of the tuberal part of the hypothalamus …

Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates
food intake and body weight. We identified leptin-sensitive neurons in the arcuate nucleus of …

Feeding is influenced by hypothalamic neuropeptides that promote (orexigenic peptides) or
inhibit feeding. Of these, neuropeptide Y (NPY) in the arcuate nucleus and melanin …

Recent studies have identified several neuropeptide systems in the hypothalamus that are
critical in the regulation of body weight. The lateral hypothalamic area (LHA) has long been …

Cells in the lateral hypothalamus and in the arcuate nucleus play prominent roles in the
central control of food intake; however, a neurochemical link connecting these potential …

Kisspeptin is the peptide product of the KiSS‐1 gene and the endogenous agonist for the
GPR54 receptor. Recent evidence suggests the kisspeptin/GPR54 system is a key regulator …

The precursor protein, proopiomelanocortin (POMC), produces many biologically active
peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte …