Lipids as mediators of cancer progression and metastasis

FCE Vogel, AB Chaves-Filho, A Schulze - Nature Cancer, 2024 - nature.com
Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …

Targeting lipid metabolism in cancer metastasis

G Pascual, B Majem, SA Benitah - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
This review delves into the most recent research on the metabolic adaptability of cancer
cells and examines how their metabolic functions can impact their progression into …

Mitochondrial disruption Nanosystem simultaneously depressed programmed death Ligand-1 and transforming growth Factor-β to overcome photodynamic …

X Jiang, L Yi, C Li, H Wang, W **ong, Y Li, Z Zhou… - ACS …, 2024 - ACS Publications
Currently, limited photosensitizers possess the capacity to reverse tumor hypoxia and
reduce programmed death ligand-1 (PD-L1) and transforming growth factor-β (TGF-β) …

Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer

B Lu, R Qiu, J Wei, L Wang, Q Zhang, M Li, X Zhan… - Nature Cancer, 2024 - nature.com
How dysregulated liquid–liquid phase separation (LLPS) contributes to the oncogenesis of
female triple-negative breast cancer (TNBC) remains unknown. Here we demonstrate that …

Mitochondrial elongation impairs breast cancer metastasis

L Minarrieta, MG Annis, Y Audet-Delage, H Kuasne… - Science …, 2024 - science.org
Mitochondrial dynamics orchestrate many essential cellular functions, including metabolism,
which is instrumental in promoting cancer growth and metastatic progression. However, how …

[HTML][HTML] Dynamic links between mechanical forces and metabolism shape the tumor milieu

R Bertolio, F Napoletano, G Del Sal - Current Opinion in Cell Biology, 2023 - Elsevier
Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

CCL2 blockade combined with PD-1/P-selectin immunomodulators impedes breast cancer brain metastasis

S Israeli Dangoor, R Khoury, K Salomon, S Pozzi… - Brain, 2024 - academic.oup.com
Over the last two decades, the diagnosis and treatment of breast cancer patients have
considerably improved. However, brain metastases remain a major clinical challenge and a …

Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling

X Li, J Tie, Y Sun, C Gong, S Deng, X Chen, S Li… - Journal of Experimental …, 2024 - Springer
Background The dynamics of mitochondrial respiratory cristae (MRC) and its impact on
oxidative phosphorylation (OXPHOS) play a crucial role in driving the progression of high …

[HTML][HTML] Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness: Current Insights and Future Directions

V Marabitti, E Vulpis, F Nazio, S Campello - Pharmacological research, 2024 - Elsevier
It is now recognized that tumors are not merely masses of transformed cells but are
intricately interconnected with healthy cells in the tumor microenvironment (TME), forming …

Arginine methylation of ddx3 by prmt1 mediates mitochondrial homeostasis to promote breast cancer metastasis

WJ Hsu, MC Chiang, YC Chao, YC Chang… - Cancer …, 2024 - aacrjournals.org
Dysregulated mitochondrial dynamics and metabolism play important roles in
tumorigenesis. Metastasizing tumor cells predominantly utilize mitochondrial metabolism …