Lipids as mediators of cancer progression and metastasis
Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …
controlled by different regulatory mechanisms. In this context, the contribution of cancer …
Targeting lipid metabolism in cancer metastasis
This review delves into the most recent research on the metabolic adaptability of cancer
cells and examines how their metabolic functions can impact their progression into …
cells and examines how their metabolic functions can impact their progression into …
Mitochondrial disruption Nanosystem simultaneously depressed programmed death Ligand-1 and transforming growth Factor-β to overcome photodynamic …
Currently, limited photosensitizers possess the capacity to reverse tumor hypoxia and
reduce programmed death ligand-1 (PD-L1) and transforming growth factor-β (TGF-β) …
reduce programmed death ligand-1 (PD-L1) and transforming growth factor-β (TGF-β) …
Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer
How dysregulated liquid–liquid phase separation (LLPS) contributes to the oncogenesis of
female triple-negative breast cancer (TNBC) remains unknown. Here we demonstrate that …
female triple-negative breast cancer (TNBC) remains unknown. Here we demonstrate that …
Mitochondrial elongation impairs breast cancer metastasis
Mitochondrial dynamics orchestrate many essential cellular functions, including metabolism,
which is instrumental in promoting cancer growth and metastatic progression. However, how …
which is instrumental in promoting cancer growth and metastatic progression. However, how …
[HTML][HTML] Dynamic links between mechanical forces and metabolism shape the tumor milieu
Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …
physiopathological processes of tissues, mechanical forces impact the structure and function …
CCL2 blockade combined with PD-1/P-selectin immunomodulators impedes breast cancer brain metastasis
Over the last two decades, the diagnosis and treatment of breast cancer patients have
considerably improved. However, brain metastases remain a major clinical challenge and a …
considerably improved. However, brain metastases remain a major clinical challenge and a …
Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling
X Li, J Tie, Y Sun, C Gong, S Deng, X Chen, S Li… - Journal of Experimental …, 2024 - Springer
Background The dynamics of mitochondrial respiratory cristae (MRC) and its impact on
oxidative phosphorylation (OXPHOS) play a crucial role in driving the progression of high …
oxidative phosphorylation (OXPHOS) play a crucial role in driving the progression of high …
[HTML][HTML] Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness: Current Insights and Future Directions
V Marabitti, E Vulpis, F Nazio, S Campello - Pharmacological research, 2024 - Elsevier
It is now recognized that tumors are not merely masses of transformed cells but are
intricately interconnected with healthy cells in the tumor microenvironment (TME), forming …
intricately interconnected with healthy cells in the tumor microenvironment (TME), forming …
Arginine methylation of ddx3 by prmt1 mediates mitochondrial homeostasis to promote breast cancer metastasis
WJ Hsu, MC Chiang, YC Chao, YC Chang… - Cancer …, 2024 - aacrjournals.org
Dysregulated mitochondrial dynamics and metabolism play important roles in
tumorigenesis. Metastasizing tumor cells predominantly utilize mitochondrial metabolism …
tumorigenesis. Metastasizing tumor cells predominantly utilize mitochondrial metabolism …