Pathogenesis of pneumonia and acute lung injury
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …
and critical care healthcare professionals, and these challenges have recently garnered …
The role of neutrophil extracellular traps in acute lung injury
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …
morbidity and mortality. Neutrophils play a key role in the development of different forms of …
A human lung alveolus-on-a-chip model of acute radiation-induced lung injury
Acute exposure to high-dose gamma radiation due to radiological disasters or cancer
radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute …
radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute …
[PDF][PDF] Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis
Extracellular cold-inducible RNA-binding protein (eCIRP) is a key mediator of severity and
mortality in sepsis. We found that stimulation of mouse bone marrow–derived neutrophils …
mortality in sepsis. We found that stimulation of mouse bone marrow–derived neutrophils …
Engineered extracellular vesicles derived from dermal fibroblasts attenuate inflammation in a murine model of acute lung injury
Acute respiratory distress syndrome (ARDS) represents a significant burden to the
healthcare system, with≈ 200 000 cases diagnosed annually in the USA. ARDS patients …
healthcare system, with≈ 200 000 cases diagnosed annually in the USA. ARDS patients …
From ICU syndromes to ICU subphenotypes: consensus report and recommendations for develo** precision medicine in the ICU
Critical care uses syndromic definitions to describe patient groups for clinical practice and
research. There is growing recognition that a “precision medicine” approach is required and …
research. There is growing recognition that a “precision medicine” approach is required and …
Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury
SK Sahu, AN Ozantürk, DH Kulkarni, L Ma… - Science …, 2023 - science.org
The complement component C3 is a fundamental plasma protein for host defense, produced
largely by the liver. However, recent work has demonstrated the critical importance of tissue …
largely by the liver. However, recent work has demonstrated the critical importance of tissue …
After the storm: regeneration, repair, and reestablishment of homeostasis between the alveolar epithelium and innate immune system following viral lung injury
JD Planer, EE Morrisey - Annual Review of Pathology …, 2023 - annualreviews.org
The mammalian lung has an enormous environmental-epithelial interface that is optimized
to accomplish the principal function of the respiratory system, gas exchange. One …
to accomplish the principal function of the respiratory system, gas exchange. One …
Acute respiratory distress syndrome
KD Wick, LB Ware, MA Matthay - bmj, 2024 - bmj.com
The understanding of acute respiratory distress syndrome (ARDS) has evolved greatly since
it was first described in a 1967 case series, with several subsequent updates to the definition …
it was first described in a 1967 case series, with several subsequent updates to the definition …
Salidroside pretreatment alleviates PM2. 5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome
S Shi, D Huang, Y Wu, C Pei, Y Wang, Z Shen… - Food and Chemical …, 2023 - Elsevier
Ambient fine particulate matter (PM 2.5) is considered a leading cause of pathogenic
particulate matter induced lung injury. And Salidroside (Sal), the major bioactive constituent …
particulate matter induced lung injury. And Salidroside (Sal), the major bioactive constituent …