Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease

C Barth, A Crestol, AMG de Lange… - The Lancet Diabetes & …, 2023 - thelancet.com
Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Beyond sex differences: short-and long-term effects of pregnancy on the brain

TA Puri, JE Richard, LAM Galea - Trends in Neurosciences, 2023 - cell.com
Growing attention has been directed to the inclusion of females in neuroscience studies, and
to the importance of studying sex as a biological variable. However, how female-specific …

Neuroanatomical changes observed over the course of a human pregnancy

L Pritschet, CM Taylor, D Cossio, J Faskowitz… - Nature …, 2024 - nature.com
Pregnancy is a period of profound hormonal and physiological changes experienced by
millions of women annually, yet the neural changes unfolding in the maternal brain …

Solving neurodegeneration: common mechanisms and strategies for new treatments

LK Wareham, SA Liddelow, S Temple… - Molecular …, 2022 - Springer
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …

Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease

S Jett, E Schelbaum, G Jang… - Frontiers in aging …, 2022 - frontiersin.org
Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological
and neurochemical processes, including those subserving cognitive function. Estradiol plays …

[HTML][HTML] Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging

JA Chowen, LM Garcia-Segura - Mechanisms of Ageing and Development, 2021 - Elsevier
Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

[HTML][HTML] The interplay of oxytocin and sex hormones

DS Quintana, BD Glaser, H Kang, ESM Kildal… - Neuroscience & …, 2024 - Elsevier
The neuropeptide oxytocin has historically been associated with reproduction and maternal
behavior. However, more recent research has uncovered that oxytocin has a much wider …

The maternal brain: Region‐specific patterns of brain aging are traceable decades after childbirth

AMG de Lange, C Barth, T Kaufmann… - Human brain …, 2020 - Wiley Online Library
Pregnancy involves maternal brain adaptations, but little is known about how parity
influences women's brain aging trajectories later in life. In this study, we replicated previous …

Characterizing the brain structural adaptations across the motherhood transition

M Martínez-García, M Paternina-Die… - Frontiers in Global …, 2021 - frontiersin.org
Women that become mothers face notable physiological adaptations during this life-period.
Neuroimaging studies of the last decade have provided grounded evidence that women's …

Enhancing brain health in the global south through a sex and gender lens

S Baez, L Castro-Aldrete, GB Britton, A Ibañez… - Nature Mental …, 2024 - nature.com
Gender inequality substantially impacts society, disproportionately disadvantaging women,
especially in the global south. This inequality correlates with brain health outcomes for …