The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …

The crucial differences between normal cells and cancer cells stem from discrete changes in
specific genes controlling proliferation and tissue homeostasis. Over 100 such cancer …

Expression of cDNA libraries from human melanoma, renal cancer, astrocytoma, and
Hodgkin disease in Escherichia coli and screening for clones reactive with high-titer IgG …

Abstract p53 antibodies (p53-Abs) were discovered 20 years ago during the course of tumor-
associated antigens screening. The discovery of p53 mutation and accumulation of p53 in …

The display of repertoires of antibody fragments on the surface of filamentous bacteriophage
offers a new way of making antibodies with predefined binding specificities. Here we …

We report the cloning and characterization of a tumor-associated carbonic anhydrase (CA)
that was identified in a human renal cell carcinoma (RCC) by serological expression …

This review summarizes studies on humoral immune responses against tumor-associated
antigens (TAAs) with a focus on antibody frequencies and the potential diagnostic …

A tacit assumption of cancer immunology has been that tumors express non-self or" foreign"
antigens. The recent identification of a handful of potentially immunogenic cancer antigens …

Antiestrogen therapy remains one of the most widely used and effective treatments for the
management of endocrine responsive breast cancers. This reflects the ability of …

TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding
transcription factor activated by stressful stimuli; it upregulates target genes involved in …