NMR spectroscopy as a characterization tool enabling biologics formulation development

J Ma, C Pathirana, DQ Liu, SA Miller - Journal of Pharmaceutical and …, 2023 - Elsevier
This review highlights recent advancements in using high resolution nuclear magnetic
resonance (NMR) spectroscopy as a characterization tool to expedite biologics formulation …

USFDA-approved parenteral peptide formulations and excipients: Industrial perspective

S Kumar, SN Sanap, M Vasoya, M Handa… - Journal of Drug Delivery …, 2024 - Elsevier
Parenteral preparations are sterile and non-pyrogenic formulations designed for delivery
into the human or animal body by injection, infusion, or implantation. Peptides are widely …

Molecular Investigation of SNAC as an Oral Peptide Permeation Enhancer in Lipid Membranes via Solid-State NMR

J Ling, R Schroder, WP Wuelfing, J Higgins… - Molecular …, 2024 - ACS Publications
Oral peptide therapeutics are increasingly favored in the pharmaceutical industry for their
ease of use and better patient adherence. However, they face challenges with poor oral …

Industrial Horizons in Pharmaceutical Science

M Brader, HYA Kim, O Koo, K Nagapudi… - Molecular …, 2024 - ACS Publications
The mission of industrial science in the pharmaceutical sector is to drive innovation in drug
development, delivery, and manufacturing, to fulfill unmet medical needs, and to provide …

In-situ biophysical characterization of high-concentration protein formulations using wNMR

J Song, M Taraban, YB Yu, L Lu, PG Biswas, W Xu… - Mabs, 2024 - Taylor & Francis
High-concentration protein formulation is of paramount importance in patient-centric drug
product development, but it also presents challenges due to the potential for enhanced …

[HTML][HTML] Interaction of preservatives with contact materials during filling and storage of parenteral liquid formulations

P Gottschalk, P Schlossbauer, L Schleicher… - European Journal of …, 2025 - Elsevier
Silicone tubing is a frequently used material in pharmaceutical filling processes for
parenteral formulations, as its characteristics like flexibility, chemical resistance and easy …

Study on the evaluation method of cigarette astringency in the simulated oral environment

X Song, S Qian, H Li, Y Shen, D Bian… - Journal of Texture …, 2024 - Wiley Online Library
Cigarettes with pronounced astringency can diminish consumers' enjoyment. However, due
to the complex composition of cigarettes, quantifying astringency intensity accurately has …

Best Practices for Submission of NMR Data to Support Higher Order Structure Assessment of Generic Peptide Drugs

K Chen, CJ Smith - The AAPS Journal, 2023 - Springer
Peptides are a growing class of therapeutics (1, 2) and defined by the US Food and Drug
Administration (FDA) as a polymer composed of 40 or fewer amino acid residues regardless …

Advances in NMR spectroscopy of small molecules in solution

P Nolis - 2023 - books.rsc.org
This book chapter covers relevant articles published in peer-reviewed journals in 2022 in
the field of NMR spectroscopy of small molecules in solution. Articles that appeared in 2022 …

Nuclear spin relaxation

J Kowalewski - 2020 - books.rsc.org
The review covers the progress in the field of NMR relaxation in fluids primarily during 2019.
Since the topic is returning to this volume SPR after a break of a few years, some highlights …