Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

It is often assumed that an animal's metabolic rate can be estimated through measuring the
whole-organism oxygen consumption rate. However, oxygen consumption alone is unlikely …

Abstract Protocols for High-Resolution FluoRespirometry of intact cells, permeabilized cells,
permeabilized muscle fibers, isolated mitochondria, and tissue homogenates offer sensitive …

Mitochondria are composed of many small proteins that control protein synthesis, complex
assembly, metabolism, and ion and reactive oxygen species (ROS) handling. We show that …

Protocols for high-resolution respirometry (HRR) of intact cells, permeabilized cells, and
permeabilized muscle fibers offer sensitive diagnostic tests of integrated mitochondrial …

Transcriptional complexes that contain peroxisome-proliferator-activated receptor
coactivator (PGC)-1α control mitochondrial oxidative function to maintain energy …

Extracellular flux (XF) analysis has become a mainstream method for measuring
mitochondrial function in cells and tissues. Although this technique is commonly used to …

Abstract Analysis of mitochondrial function is central to the study of intracellular energy
metabolism, mechanisms of cell death and pathophysiology of a variety of human diseases …

The current study addresses a novel hypothesis of subcellular distribution of mitochondrial
dysfunction in skeletal muscle in type 2 diabetes. Vastus lateralis muscle was obtained by …

The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-
γ coactivator-1α (PGC-1α) was targeted in mice. PGC-1α null (PGC-1α−/−) mice were viable …