Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …
embryonic and organ development, as well as cancer progression. Genome-wide …
Chronic tissue inflammation and metabolic disease
YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
[HTML][HTML] RNA sequencing of single human islet cells reveals type 2 diabetes genes
Y **n, J Kim, H Okamoto, M Ni, Y Wei, C Adler… - Cell metabolism, 2016 - cell.com
Pancreatic islet cells are critical for maintaining normal blood glucose levels, and their
malfunction underlies diabetes development and progression. We used single-cell RNA …
malfunction underlies diabetes development and progression. We used single-cell RNA …
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
AS Axelsson, E Tubbs, B Mecham, S Chacko… - Science translational …, 2017 - science.org
A potentially useful approach for drug discovery is to connect gene expression profiles of
disease-affected tissues (“disease signatures”) to drug signatures, but it remains to be …
disease-affected tissues (“disease signatures”) to drug signatures, but it remains to be …
Type 2 diabetes mellitus: from a metabolic disorder to an inflammatory condition
I Hameed, SR Masoodi, SA Mir, M Nabi… - World journal of …, 2015 - pmc.ncbi.nlm.nih.gov
Diabetes mellitus is increasing at an alarming rate and has become a global challenge.
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …
Islet inflammation in type 2 diabetes
M Böni-Schnetzler, DT Meier - Seminars in immunopathology, 2019 - Springer
Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …
[HTML][HTML] Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes
SZ Hasnain, JB Prins… - Journal of molecular …, 2016 - jme.bioscientifica.com
The inability of pancreatic β-cells to make sufficient insulin to control blood sugar is a central
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …
Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity
MY Donath, É Dalmas, NS Sauter, M Böni-Schnetzler - Cell metabolism, 2013 - cell.com
The role of the immune system is to restore functionality in response to stress. Increasing
evidence shows that this function is not limited to insults by infection or injury and plays a …
evidence shows that this function is not limited to insults by infection or injury and plays a …