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Wnt–β-catenin signalling in liver development, health and disease
MJ Perugorria, P Olaizola, I Labiano… - Nature reviews …, 2019 - nature.com
The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …
β-catenin signaling and roles in liver homeostasis, injury, and tumorigenesis
SP Monga - Gastroenterology, 2015 - Elsevier
β-catenin (encoded by CTNNB1) is a subunit of the cell surface cadherin protein complex
that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its …
that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its …
[PDF][PDF] Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It
encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular …
encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular …
[HTML][HTML] Phosphorylation of β-catenin by AKT promotes β-catenin transcriptional activity
Increased transcriptional activity of β-catenin resulting from Wnt/Wingless-dependent or-
independent signaling has been detected in many types of human cancer, but the …
independent signaling has been detected in many types of human cancer, but the …
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
The Wnt signalling pathway is essential for development and organogenesis 1, 2, 3. Wnt
signalling stabilizes β-catenin, which accumulates in the cytoplasm, binds to T-cell factor …
signalling stabilizes β-catenin, which accumulates in the cytoplasm, binds to T-cell factor …
How CLSPN could demystify its prognostic value and potential molecular mechanism for hepatocellular carcinoma: a crosstalk study
Y Shi, Y Wang, K Niu, W Zhang, Q Lv… - Computers in Biology and …, 2024 - Elsevier
Background & aims CLSPN, a critical component of the S-phase checkpoint in response to
DNA replication stress, has been implicated in the pathogenesis of multiple tumor types. The …
DNA replication stress, has been implicated in the pathogenesis of multiple tumor types. The …
Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
Activation of Wnt signaling through β-catenin mutations contributes to the development of
hepatocellular carcinoma (HCC) and hepatoblastoma (HB). To explore the contribution of …
hepatocellular carcinoma (HCC) and hepatoblastoma (HB). To explore the contribution of …
[PDF][PDF] Octamer 4/microRNA‐1246 signaling axis drives Wnt/β‐catenin activation in liver cancer stem cells
Wnt/β‐catenin signaling is activated in CD133 liver cancer stem cells (CSCs), a subset of
cells known to be a root of tumor recurrence and therapy resistance in hepatocellular …
cells known to be a root of tumor recurrence and therapy resistance in hepatocellular …
[PDF][PDF] MAdCAM‐1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM‐1 in chronic …
Mucosal addressin cell adhesion molecule (MAdCAM‐1) plays a pivotal role in T‐
lymphocyte homing to the gut. Given the strong association between the autoimmune liver …
lymphocyte homing to the gut. Given the strong association between the autoimmune liver …
The links between axin and carcinogenesis
The products of the two mammalian Axin genes (Axin1 and its homologue Axin2) are
essential for the degradation of β catenin, a component of Wnt signalling that is frequently …
essential for the degradation of β catenin, a component of Wnt signalling that is frequently …