Assessing the ecological risks of per‐and polyfluoroalkyl substances: Current state‐of‐the science and a proposed path forward

GT Ankley, P Cureton, RA Hoke… - Environmental …, 2021 - academic.oup.com
Per‐and poly‐fluoroalkyl substances (PFAS) encompass a large, heterogenous group of
chemicals of potential concern to human health and the environment. Based on information …

Immunotoxic effects of environmental pollutants in marine mammals

JPW Desforges, C Sonne, M Levin, U Siebert… - Environment …, 2016 - Elsevier
Due to their marine ecology and life-history, marine mammals accumulate some of the
highest levels of environmental contaminants of all wildlife. Given the increasing prevalence …

Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview

W Brack, S Ait-Aissa, RM Burgess, W Busch… - Science of the Total …, 2016 - Elsevier
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …

[HTML][HTML] IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making

X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

In vitro to in vivo extrapolation for high throughput prioritization and decision making

SM Bell, X Chang, JF Wambaugh, DG Allen, M Bartels… - Toxicology in vitro, 2018 - Elsevier
In vitro chemical safety testing methods offer the potential for efficient and economical tools
to provide relevant assessments of human health risk. To realize this potential, methods are …

Environmental chemistry of organosiloxanes

C Rücker, K Kümmerer - Chemical Reviews, 2015 - ACS Publications
Although around us for more than six decades, siloxanes are considered emerging
environmental contaminants. 1− 5 Emerging here means that previously they were not …

[HTML][HTML] Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models

S Proença, BI Escher, FC Fischer, C Fisher, S Grégoire… - Toxicology in Vitro, 2021 - Elsevier
Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …

Quantitative adverse outcome pathways and their application to predictive toxicology

RB Conolly, GT Ankley, WY Cheng… - … science & technology, 2017 - ACS Publications
A quantitative adverse outcome pathway (qAOP) consists of one or more biologically based,
computational models describing key event relationships linking a molecular initiating event …

A next-generation risk assessment case study for coumarin in cosmetic products

MT Baltazar, S Cable, PL Carmichael… - Toxicological …, 2020 - academic.oup.com
Abstract Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven
risk assessment approach that integrates new approach methodologies (NAMs) to assure …

[ΒΙΒΛΙΟ][B] Bioanalytical tools in water quality assessment

P Neale, F Leusch, B Escher - 2021 - library.oapen.org
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …