Severe malaria is a medical emergency. It is a major cause of preventable childhood death
in tropical countries. Severe malaria justifies considerable global investment in malaria …

Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases
and deaths are estimated to occur in low and middle-income countries. Barriers to reducing …

Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Background Severe malaria is a major cause of childhood death and often the main reason
for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established …

Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was
first documented. However, its continued use is challenged by its poor tolerability, poor …

Species-specific diagnosis is important to guide appropriate primaquine administration for
gametocytocidal treatment of falciparum malaria to reduce transmission in endemic areas …

Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Antimicrobial resistance (AMR) is a global health and one health problem. Efforts to mitigate
the problem of AMR are challenging to implement due to unresolved ethical tensions. We …

Background Artesunate is an antimalarial agent with broad anti-cancer activity in in vitro and
animal experiments and case reports. Artesunate has not been studied in rigorous clinical …

Background Delay in receiving treatment for uncomplicated malaria (UM) is often reported to
increase the risk of develo** severe malaria (SM), but access to treatment remains low in …