Peptidomics

R Hellinger, A Sigurdsson, W Wu… - Nature Reviews …, 2023 - nature.com
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

Introducing the bacterial and viral bioinformatics resource center (BV-BRC): a resource combining PATRIC, IRD and ViPR

RD Olson, R Assaf, T Brettin, N Conrad… - Nucleic acids …, 2023 - academic.oup.com
Abstract The National Institute of Allergy and Infectious Diseases (NIAID) established the
Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the …

The evolution, assembly, and dynamics of marine Holobionts

RA González-Pech, VY Li, V Garcia… - Annual Review of …, 2024 - annualreviews.org
The holobiont concept (ie, multiple living beings in close symbiosis with one another and
functioning as a unit) is revolutionizing our understanding of biology, especially in marine …

Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei

K Billington, C Halliday, R Madden, P Dyer… - Nature …, 2023 - nature.com
Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

The 2022 Nucleic Acids Research database issue and the online molecular biology database collection

DJ Rigden, XM Fernández - Nucleic acids research, 2022 - academic.oup.com
Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell

A Guérin, KM Strelau, K Barylyuk, BA Wallbank… - Cell host & …, 2023 - cell.com
Cryptosporidium is a leading cause of diarrheal disease in children and an important
contributor to early childhood mortality. The parasite invades and extensively remodels …

A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum

AA Morano, RM Rudlaff, JD Dvorin - Nature Communications, 2023 - nature.com
During its asexual blood stage, P. falciparum replicates via schizogony, wherein dozens of
daughter cells are formed within a single parent. The basal complex, a contractile ring that …

Babesia duncani multi-omics identifies virulence factors and drug targets

P Singh, S Lonardi, Q Liang, P Vydyam… - Nature …, 2023 - nature.com
Babesiosis is a malaria-like disease in humans and animals that is caused by Babesia
species, which are tick-transmitted apicomplexan pathogens. Babesia duncani causes …

Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

J Ajiboye, JE Teixeira, M Gasonoo, EB Mattice… - Nature …, 2024 - nature.com
Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in
children and immunocompromised people. There is only one approved treatment that is …

The P10K database: a data portal for the protist 10 000 genomes project

X Gao, K Chen, J **ong, D Zou, F Yang… - Nucleic Acids …, 2024 - academic.oup.com
Protists, a highly diverse group of microscopic eukaryotic organisms distinct from fungi,
animals and plants, exert crucial roles within the earth's biosphere. However, the genomes …