Threat-anticipatory defensive responses have evolved to promote survival in a dynamic
world. While inherently adaptive, aberrant expression of defensive responses to potential …

Generalized anxiety disorder (GAD) is associated with significant morbidity in children and
adolescents, yet only recently have the neuropharmacology and neurophysiology of this …

A common assumption is that all youth with anxiety disorders (AD) experience impaired peer
relationships relative to healthy control children. Social impairments have been identified …

Social anxiety disorder (SAD) in children is often comorbid with generalized anxiety disorder
(GAD). We investigated whether worry, intolerance of uncertainty, beliefs about worry …

Objective: This is a feasibility study evaluating the safety, tolerability, and potential anxiolytic
efficacy of the α2 agonist guanfacine extended-release (GXR) in children and adolescents …

Adolescence is a period of significant physical, social and emotional change and therefore a
vulnerable period for the development of mental illness. Many psychiatric disorders have …

Abstract The serotonin 1B receptor (5-HT 1B) is important to both the pathogenesis of major
depressive disorder and the antidepressant effects of selective serotonin reuptake inhibitors …

There is little known about pharmacogenetic of fluoxetine in children and adolescents. In this
study, we evaluate, for the first time, the influence of CYP2D6, CYP2C9 and ABCB1 …

This paper first summarizes the main findings of clinical studies conducted over the past two
and a half decades on psychopathology (ie, psychiatric diagnoses, behavior and emotional …

Activity-based anorexia is a paradigm that induces increased physical activity, reduced food
intake, and heightened activity of the hypothalamic-pituitary-adrenal axis in adult rats. To …