Immunomodulatory nanosystems

X Feng, W Xu, Z Li, W Song, J Ding… - Advanced science, 2019 - Wiley Online Library
Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Chemical communication at the synthetic cell/living cell interface

V Mukwaya, S Mann, H Dou - Communications Chemistry, 2021 - nature.com
Although the complexity of synthetic cells has continued to increase in recent years,
chemical communication between protocell models and living organisms remains a key …

Nanoparticle-based immunotherapy for cancer

K Shao, S Singha, X Clemente-Casares, S Tsai… - ACS …, 2015 - ACS Publications
The design of nanovaccines capable of triggering effective antitumor immunity requires an
understanding of how the immune system senses and responds to threats, including …

Materials for immunotherapy

CW Shields IV, LLW Wang, MA Evans… - Advanced …, 2020 - Wiley Online Library
Breakthroughs in materials engineering have accelerated the progress of immunotherapy in
preclinical studies. The interplay of chemistry and materials has resulted in improved …

Cutting edge: predetermined avidity of human CD8 T cells expanded on calibrated MHC/anti-CD28-coated microspheres

S Walter, L Herrgen, O Schoor, G Jung… - The Journal of …, 2003 - journals.aai.org
Cytotoxic CD8 T cells are key effectors in the immunotherapy of malignant and viral
diseases. However, the lack of efficient methods for their in vitro priming and expansion has …

Adoptive-cell-transfer therapy for the treatment of patients with cancer

ME Dudley, SA Rosenberg - Nature Reviews Cancer, 2003 - nature.com
Adoptive immunotherapy—the isolation of antigen-specific cells, their ex vivo expansion and
activation, and subsequent autologous administration—is a promising approach to inducing …

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

MA Pulè, KC Straathof, G Dotti, HE Heslop… - Molecular Therapy, 2005 - cell.com
The transduction of primary T cells to express chimeric T cell receptors (cTCR) for redirected
targeting of tumor cells is an attractive strategy for generating tumor-specific T cells for …

Recent advances in biomaterial-boosted adoptive cell therapy

Y Xue, J Che, X Ji, Y Li, J ** artificial antigen-presenting cells
LJ Eggermont, LE Paulis, J Tel, CG Figdor - Trends in biotechnology, 2014 - cell.com
Active anti-cancer immune responses depend on efficient presentation of tumor antigens
and co-stimulatory signals by antigen-presenting cells (APCs). Therapy with autologous …

A carbon nanotube–polymer composite for T-cell therapy

TR Fadel, FA Sharp, N Vudattu, R Ragheb… - Nature …, 2014 - nature.com
Clinical translation of cell therapies requires strategies that can manufacture cells efficiently
and economically. One promising way to reproducibly expand T cells for cancer therapy is …