Pathophysiology of type 2 diabetes mellitus

U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

[HTML][HTML] Antiplatelet therapy after percutaneous coronary intervention

DJ Angiolillo, M Galli, JP Collet, A Kastrati… - …, 2022 - ncbi.nlm.nih.gov
Antiplatelet therapy is key to reducing local thrombotic complications and systemic
ischaemic events among patients undergoing percutaneous coronary interventions (PCI) …

How western diet and lifestyle drive the pandemic of obesity and civilization diseases

W Kopp - Diabetes, metabolic syndrome and obesity: targets and …, 2019 - Taylor & Francis
Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

C Franceschi, P Garagnani, P Parini… - Nature Reviews …, 2018 - nature.com
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

[HTML][HTML] Inflammation and cardiovascular disease: From mechanisms to therapeutics

A Alfaddagh, SS Martin, TM Leucker, ED Michos… - American journal of …, 2020 - Elsevier
Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

Inflammatory responses and inflammation-associated diseases in organs

L Chen, H Deng, H Cui, J Fang, Z Zuo, J Deng… - …, 2017 - pmc.ncbi.nlm.nih.gov
Inflammation is a biological response of the immune system that can be triggered by a
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …

Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease

DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …

COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies

D Atri, HK Siddiqi, JP Lang, V Nauffal… - Basic to Translational …, 2020 - jacc.org
Summary Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As …

Atherosclerosis and inflammation: overview and updates

GR Geovanini, P Libby - Clinical science, 2018 - portlandpress.com
The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis
and its complications has gained considerable attention, but has not yet entered clinical …