Animal studies indicate that the composition of gut microbiota may be involved in the
progression of insulin resistance to type 2 diabetes. Probiotics and/or prebiotics could be a …

Hepatic lipid metabolism is a series of complex processes that control influx and efflux of not
only hepatic lipid pools, but also organismal pools. Lipid homeostasis is usually tightly …

The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …

Obesity is reaching global epidemic proportions as a result of factors such as high-calorie
diets and lack of physical exercise. Obesity is now considered to be a medical condition …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Metabolic syndrome is thought to result from obesity and obesity-linked insulin resistance.
Obesity in adulthood is characterized by adipocyte hypertrophy. Adipose tissue participates …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Context: Adipose tissue is a metabolically dynamic organ, serving as a buffer to control fatty
acid flux and a regulator of endocrine function. In obese subjects, and those with type 2 …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

Insulin resistance (IR), a key component of the metabolic syndrome, precedes the
development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological …