Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes
The development of implantable neuroelectrodes is advancing rapidly as these tools are
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
Potential for thermal damage to the blood–brain barrier during craniotomy: implications for intracortical recording microelectrodes
AJ Shoffstall, JE Paiz, DM Miller, GM Rial… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Our objective was to determine how readily disruption of the blood–brain barrier
(BBB) occurred as a result of bone drilling during a craniotomy to implant microelectrodes in …
(BBB) occurred as a result of bone drilling during a craniotomy to implant microelectrodes in …
Electropolymerization processing of side-chain engineered EDOT for high performance microelectrode arrays
M Ghazal, A Susloparova, C Lefebvre… - Biosensors and …, 2023 - Elsevier
Abstract Microelectrode Arrays (MEAs) are popular tools for in vitro extracellular recording.
They are often optimized by surface engineering to improve affinity with neurons and …
They are often optimized by surface engineering to improve affinity with neurons and …
Foreign body response to intracortical microelectrodes is not altered with dip-coating of polyethylene glycol (PEG)
Poly (ethylene glycol)(PEG) is a frequently used polymer for neural implants due to its
biocompatible property. As a follow-up to our recent study that used PEG for stiffening …
biocompatible property. As a follow-up to our recent study that used PEG for stiffening …
A critical review of cell culture strategies for modelling intracortical brain implant material reactions
The capacity to predict in vivo responses to medical devices in humans currently relies
greatly on implantation in animal models. Researchers have been striving to develop in vitro …
greatly on implantation in animal models. Researchers have been striving to develop in vitro …
Bioinspired materials and systems for neural interfacing
AJ Shoffstall, JR Capadona - Current Opinion in Biomedical Engineering, 2018 - Elsevier
Brain-implanted devices have a number of applications with significant potential.
Widespread adoption hinges on the ability to produce an interface that can engage with …
Widespread adoption hinges on the ability to produce an interface that can engage with …
A 3D in vitro model of the device-tissue interface: functional and structural symptoms of innate neuroinflammation are mitigated by antioxidant ceria nanoparticles
E Atherton, Y Hu, S Brown, E Papiez… - Journal of Neural …, 2022 - iopscience.iop.org
Objective. The recording instability of neural implants due to neuroinflammation at the
device-tissue interface is a primary roadblock to broad adoption of brain-machine interfaces …
device-tissue interface is a primary roadblock to broad adoption of brain-machine interfaces …
An Improved in vitro Model of Cortical Tissue
Intracortical electrodes for brain–machine interfaces rely on intimate contact with tissues for
recording signals and stimulating neurons. However, the long-term viability of intracortical …
recording signals and stimulating neurons. However, the long-term viability of intracortical …
[HTML][HTML] Neurons self-organize around salivary epithelial cells in novel co-culture model
S Sommakia, OJ Baker - Journal of stem cell and regenerative …, 2016 - ncbi.nlm.nih.gov
Salivary gland bioengineering requires understanding the interaction between salivary
epithelium and surrounding tissues. An important component of salivary glands is the …
epithelium and surrounding tissues. An important component of salivary glands is the …
Improving the brain machine interface via multiple Tetramethyl Orthosilicate sol-gel coatings on microelectrode arrays
MD McDermott, J Zhang, KJ Otto - 2015 7th International IEEE …, 2015 - ieeexplore.ieee.org
The failure of neurally implanted microelectrode arrays has been highly correlated with the
foreign body response (FBR). In order to maintain high fidelity signaling across the brain …
foreign body response (FBR). In order to maintain high fidelity signaling across the brain …