Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes

M Gulino, D Kim, S Pané, SD Santos… - Frontiers in …, 2019 - frontiersin.org
The development of implantable neuroelectrodes is advancing rapidly as these tools are
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …

Potential for thermal damage to the blood–brain barrier during craniotomy: implications for intracortical recording microelectrodes

AJ Shoffstall, JE Paiz, DM Miller, GM Rial… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Our objective was to determine how readily disruption of the blood–brain barrier
(BBB) occurred as a result of bone drilling during a craniotomy to implant microelectrodes in …

Electropolymerization processing of side-chain engineered EDOT for high performance microelectrode arrays

M Ghazal, A Susloparova, C Lefebvre… - Biosensors and …, 2023 - Elsevier
Abstract Microelectrode Arrays (MEAs) are popular tools for in vitro extracellular recording.
They are often optimized by surface engineering to improve affinity with neurons and …

Foreign body response to intracortical microelectrodes is not altered with dip-coating of polyethylene glycol (PEG)

HC Lee, J Gaire, SW Currlin, MD McDermott… - Frontiers in …, 2017 - frontiersin.org
Poly (ethylene glycol)(PEG) is a frequently used polymer for neural implants due to its
biocompatible property. As a follow-up to our recent study that used PEG for stiffening …

A critical review of cell culture strategies for modelling intracortical brain implant material reactions

AD Gilmour, AJ Woolley, LA Poole-Warren… - Biomaterials, 2016 - Elsevier
The capacity to predict in vivo responses to medical devices in humans currently relies
greatly on implantation in animal models. Researchers have been striving to develop in vitro …

Bioinspired materials and systems for neural interfacing

AJ Shoffstall, JR Capadona - Current Opinion in Biomedical Engineering, 2018 - Elsevier
Brain-implanted devices have a number of applications with significant potential.
Widespread adoption hinges on the ability to produce an interface that can engage with …

A 3D in vitro model of the device-tissue interface: functional and structural symptoms of innate neuroinflammation are mitigated by antioxidant ceria nanoparticles

E Atherton, Y Hu, S Brown, E Papiez… - Journal of Neural …, 2022 - iopscience.iop.org
Objective. The recording instability of neural implants due to neuroinflammation at the
device-tissue interface is a primary roadblock to broad adoption of brain-machine interfaces …

An Improved in vitro Model of Cortical Tissue

A Gilmour, L Poole-Warren, RA Green - Frontiers in Neuroscience, 2019 - frontiersin.org
Intracortical electrodes for brain–machine interfaces rely on intimate contact with tissues for
recording signals and stimulating neurons. However, the long-term viability of intracortical …

[HTML][HTML] Neurons self-organize around salivary epithelial cells in novel co-culture model

S Sommakia, OJ Baker - Journal of stem cell and regenerative …, 2016 - ncbi.nlm.nih.gov
Salivary gland bioengineering requires understanding the interaction between salivary
epithelium and surrounding tissues. An important component of salivary glands is the …

Improving the brain machine interface via multiple Tetramethyl Orthosilicate sol-gel coatings on microelectrode arrays

MD McDermott, J Zhang, KJ Otto - 2015 7th International IEEE …, 2015 - ieeexplore.ieee.org
The failure of neurally implanted microelectrode arrays has been highly correlated with the
foreign body response (FBR). In order to maintain high fidelity signaling across the brain …