IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity
M Gómez-Herranz, J Taylor, RD Sloan - Journal of Biological Chemistry, 2023 - ASBMB
Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
IFITM-family proteins: the cell's first line of antiviral defense
CC Bailey, G Zhong, IC Huang… - Annual review of …, 2014 - annualreviews.org
Animal cells use a wide variety of mechanisms to slow or prevent replication of viruses.
These mechanisms are usually mediated by antiviral proteins whose expression and …
These mechanisms are usually mediated by antiviral proteins whose expression and …
IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion
TM Desai, M Marin, CR Chin, G Savidis… - PLoS …, 2014 - journals.plos.org
Interferon-induced transmembrane proteins (IFITMs) inhibit infection of diverse enveloped
viruses, including the influenza A virus (IAV) which is thought to enter from late endosomes …
viruses, including the influenza A virus (IAV) which is thought to enter from late endosomes …
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread
The interferon-induced transmembrane (IFITM) proteins protect cells from diverse virus
infections by inhibiting virus-cell fusion. IFITM proteins also inhibit HIV-1 replication through …
infections by inhibiting virus-cell fusion. IFITM proteins also inhibit HIV-1 replication through …
Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?
Transforming growth factor-beta (TGF-β) is a member of a family of secreted cytokines with
vital biological functions in cells. The abnormal expression of TGF-β signaling is a common …
vital biological functions in cells. The abnormal expression of TGF-β signaling is a common …
IFITM proteins restrict HIV-1 infection by antagonizing the envelope glycoprotein
The interferon-induced transmembrane (IFITM) proteins have been recently shown to restrict
HIV-1 and other viruses. Here, we provide evidence that IFITM proteins, particularly IFITM2 …
HIV-1 and other viruses. Here, we provide evidence that IFITM proteins, particularly IFITM2 …
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43
X Zhao, F Guo, F Liu, A Cuconati… - Proceedings of the …, 2014 - National Acad Sciences
IFNs are a family of cytokines that are essential for the antiviral response in vertebrates. Not
surprisingly, viruses have adapted to encode virulence factors to cope with the IFN …
surprisingly, viruses have adapted to encode virulence factors to cope with the IFN …
The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry
SK Narayana, KJ Helbig, EM McCartney… - Journal of Biological …, 2015 - ASBMB
The interferon-induced transmembrane (IFITM) family of proteins have recently been
identified as important host effector molecules of the type I interferon response against …
identified as important host effector molecules of the type I interferon response against …
IFITM 3 requires an amphipathic helix for antiviral activity
Interferon‐induced transmembrane protein 3 (IFITM 3) is a cellular factor that blocks virus
fusion with cell membranes. IFITM 3 has been suggested to alter membrane curvature and …
fusion with cell membranes. IFITM 3 has been suggested to alter membrane curvature and …
IFITM proteins—cellular inhibitors of viral entry
Highlights•IFITMs are interferon inducible membrane proteins that restrict viral
infection.•Influenza infection is exacerbated in Ifitm3−/− mice.•A SNP in IFITM3 may increase …
infection.•Influenza infection is exacerbated in Ifitm3−/− mice.•A SNP in IFITM3 may increase …