Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …

Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …

Intensive research over the past 2 decades has implicated ceramide in the regulation of
several cell responses. However, emerging evidence points to dramatic complexities in …

Sphingolipid metabolism in metazoan cells consists of a complex interconnected web of
numerous enzymes, metabolites and modes of regulation. At the centre of sphingolipid …

Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of
obesity and insulin resistance. However, the mechanistic link between these processes …

Ceramides are a class of sphingolipids that are abundant in cell membranes. They are
important structural components of the membrane but can also act as second messengers in …

Mitochondria in the cell are the center for energy production, essential biomolecule
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …