Glioma targeted therapy: insight into future of molecular approaches
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease
V Rothhammer, FJ Quintana - Nature Reviews Immunology, 2019 - nature.com
The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …
processes in health and disease. However, our understanding of the molecular pathways …
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
G Agliardi, AR Liuzzi, A Hotblack, D De Feo… - Nature …, 2021 - nature.com
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR) …
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR) …
Targeting immunosuppressive adenosine in cancer
Despite the success of anti-programmed cell death protein 1 (PD1), anti-PD1 ligand 1
(PDL1) and anti-cytotoxic T lymphocyte antigen 4 (CTLA4) therapies in advanced cancer, a …
(PDL1) and anti-cytotoxic T lymphocyte antigen 4 (CTLA4) therapies in advanced cancer, a …
ATP and cancer immunosurveillance
While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …
Big opportunities for small molecules in immuno-oncology
JL Adams, J Smothers, R Srinivasan… - Nature reviews Drug …, 2015 - nature.com
The regulatory approval of ipilimumab (Yervoy) in 2011 ushered in a new era of cancer
immunotherapies with durable clinical effects. Most of these breakthrough medicines are …
immunotherapies with durable clinical effects. Most of these breakthrough medicines are …
Immunosuppressive activities of adenosine in cancer
Highlights•Adenosine protects tissues against excessive inflammation and promotes tissue
repair.•The adenosine pathway is hijacked to dampen anti-tumor immunity.•Targeting CD73 …
repair.•The adenosine pathway is hijacked to dampen anti-tumor immunity.•Targeting CD73 …
Anti-CD73 in cancer immunotherapy: awakening new opportunities
Over recent years, significant advances in cancer immunotherapy have been made due to a
better understanding of the principles underlying tumor biology and immunology. In this …
better understanding of the principles underlying tumor biology and immunology. In this …
Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian …
AD Garg, D De Ruysscher, P Agostinis - Oncoimmunology, 2016 - Taylor & Francis
The emerging role of the cancer cell-immune cell interface in sha** tumorigenesis/
anticancer immunotherapy has increased the need to identify prognostic biomarkers …
anticancer immunotherapy has increased the need to identify prognostic biomarkers …
Targeting the CD73-adenosine axis in immuno-oncology
The ectonucleotidases CD39 and CD73 are cell surface enzymes that catabolize the
breakdown of extracellular ATP into adenosine. As such, they constitute critical components …
breakdown of extracellular ATP into adenosine. As such, they constitute critical components …