The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

Fibrosis is the abnormal deposition of extracellular matrix, characterized by accumulation of
collagen and other extracellular matrix components, which causes organ dysfunction and …

Circulating proteomic signatures of age are closely associated with aging and age-related
diseases; however, the utility of changes in secreted proteins in identifying therapeutic …

Peritoneal fibrosis is a complication of long-term peritoneal dialysis (PD) that restricts its
clinical application for the treatment of end-stage renal disease. Lactobacillus casei Zhang …

The characteristic feature of chronic peritoneal damage in peritoneal dialysis (PD) is a
decline in ultrafiltration capacity associated with pathological fibrosis and angiogenesis. The …

Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage
of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney …

Peritoneal inflammation and fibrosis remain major challenges to the long-term maintenance
of peritoneal dialysis. Pemafibrate, a selective peroxisome proliferator-activated receptor α …

Transglutaminases (TGs) are a family of protein cross-linking enzymes that are capable of
stiffening and insolubilizing proteins and creating protein networks, and thereby altering …

Peritoneal fibrosis is the final process of progressive changes in the peritoneal membrane
due to chronic inflammation and infection. It is one of the main causes of discontinuation of …

Background Despite the significant progress achieved in understanding the pathology and
clinical management of SARS-CoV-2 infection, still pathogenic and clinical issues need to …