The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Our populations are aging. Some experts predict that 30% of hospital beds will soon be
occupied by osteoporosis patients. Statistics show that 20% of patients suffering from an …

Autologous bone graft is considered as the gold standard in bone reconstructive surgery.
However, the quantity of bone available is limited and the harvesting procedure requires a …

Microporosity has a critical role in improving the osteogenesis of scaffolds for bone tissue
engineering. Although the exact mechanism, by which it promotes new bone formation, is …

Calcium phosphate (CaP) ceramics have been widely used for bone regeneration because
of their ability to induce osteogenesis. Surface properties, including chemical composition …

Some biomaterials are osteoinductive, that is, they are able to trigger the osteogenic process
by inducing the differentiation of mesenchymal stem cells to the osteogenic lineage …

The repair and regeneration of articular cartilage represent important challenges for
orthopedic investigators and surgeons worldwide due to its avascular, aneural structure …

The number of patients with bone defects caused by various bone diseases is increasing
yearly in the aging population, and people are paying increasing attention to bone tissue …

Additive manufacturing of porous Ti6Al4V (Ti64) parts is promising for biomedical
applications. In this study, Ti64 scaffolds with two scales of interconnected porosity networks …

With the increasing demand for novel bone repair solutions that overcome the drawbacks of
current grafting techniques, the design of artificial bone scaffolds is a central focus in bone …