Modern interest in muscarinic acetylcholine receptor (mAChR) activators for schizophrenia
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …

Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that
mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR …

Because activation of D2 receptors reverses the neurochemical effects of cannabinoids, we
examined whether increasing dopaminergic tone in the globus pallidus (GPe) switches …

We focus on dynamical descriptions of short-term synaptic plasticity. Instead of focusing on
the molecular machinery that has been reviewed recently by several authors, we …

This chapter describes the anatomical and physiological organization of the external and
internal segments of the globus pallidus (GPe and GPi, respectively). A large section is …

Most neurons in the striatum are projection neurons (SPNs) which make synapses with each
other within distances of approximately 100 µm. About 5% of striatal neurons are GABAergic …

We employed the whole-cell patch-clamp method and ChAT-Cre mice to study the
electrophysiological attributes of cholinergic neurons in the external globus pallidus. Most …

We have analyzed the influence of acetylcholine and GABAergic inhibitory transmission on
the functioning of parallel topically organized cortico-basal ganglia–thalamo-cortical neural …

We characterized transmission from the pedunculopotine tegmental nucleus (PPTg), which
contains cholinergic and glutamatergic neurons, at synapses with noradrenergic (NAergic) …

Cholinergic neurotransmission exerts widespread modulation of brain function. The focus of
my thesis is to detail the neurophysiological and behavioural function of acetylcholine in the …