In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA
intermediates from which protein products are synthesized. Transcriptional enhancers are …

Consciousness and Neuroscience Consciousness and Neuroscience Francis Crick The Salk
Institute and Christof Koch Computation and Neural Systems Program California Institute of …

In recent years, tetracyclines, such as doxycycline, have become broadly used to control
gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

The ability to dynamically manipulate the transcriptome is important for studying how gene
networks direct cellular functions and how network perturbations cause disease. Nuclease …

▪ Abstract Cys2His2 zinc finger proteins offer a stable and versatile framework for the design
of proteins that recognize desired target sites on double-stranded DNA. Individual fingers …

Molecular techniques now allow the design of precise genetic modifications in the mouse.
Not only can defined nucleotide changes be engineered into the genome of the mouse, but …

Mouse genetic manipulation has provided an excellent system to characterize gene function
in numerous contexts. A number of mutants have been produced by using transgenic, gene …

The art and science of gene therapy has received much attention of late. The tragic death of
18-year-old Jesse Gelsinger, a volunteer in a Phase I clinical trial, has overshadowed the …

Publisher Summary This chapter discusses the ecdysone receptors and their biological
actions. It also summarizes the insect endocrinology and the roles of these steroids in the …