The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …

The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb …

Fibroblast growth factor 21 (FGF21) has been identified as a potent metabolic regulator.
Administration of recombinant FGF21 protein to rodents and rhesus monkeys with diet …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide.
HCC progression and metastasis are closely related to altered mitochondrial metabolism …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

Physicians should be aware of porphyrias, which could be responsible for unexplained
gastrointestinal, neurologic, or skin disorders. Despite their relative rarity and complexity …