The ability of a cell to properly express its genes depends on optimal transcription and
splicing. RNA polymerase II (RNAPII) transcribes protein-coding genes and produces pre …

Plants exhibit an enormous phenotypic plasticity to adjust to changing environmental
conditions. For this purpose, they have evolved mechanisms to detect and measure biotic …

Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1
gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot …

Alternative splicing (AS) enables differential inclusion of exons from a given transcript,
thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play …

Familial dysautonomia (FD) is a currently untreatable, neurodegenerative disease caused
by a splicing mutation (c. 2204+ 6T> C) that causes skip** of exon 20 of the elongator …

Triple-negative breast cancer (TNBC), although highly lethal, lacks validated therapeutic
targets. Here, we report that U2 snRNP-associated SURP motif-containing protein …

Simple Summary RBM22 is a gene that encodes an essential RNA-Binding Protein involved
in pre-mRNA splicing and transcription, with a DNA-binding function. This dual RNA/DNA …

Long noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their
expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell …

RNA splicing is the process of forming mature mRNA, which is an essential phase
necessary for gene expression and controls many aspects of cell proliferation, survival, and …

Colorectal cancer (CRC) is one of the leading causes of cancer‐related death worldwide.
The existence of cancer stem cells (CSC) causes tumor relapses, metastasis, and resistance …