The dawn of spatial omics

D Bressan, G Battistoni, GJ Hannon - Science, 2023 - science.org
Spatial omics has been widely heralded as the new frontier in life sciences. This term
encompasses a wide range of techniques that promise to transform many areas of biology …

Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research

HE Park, SH Jo, RH Lee, CP Macks, T Ku… - Advanced …, 2023 - Wiley Online Library
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …

High-throughput single nucleus total RNA sequencing of formalin-fixed paraffin-embedded tissues by snRandom-seq

Z Xu, T Zhang, H Chen, Y Zhu, Y Lv, S Zhang… - Nature …, 2023 - nature.com
Formalin-fixed paraffin-embedded (FFPE) tissues constitute a vast and valuable patient
material bank for clinical history and follow-up data. It is still challenging to achieve single …

Deep 3D histology powered by tissue clearing, omics and AI

A Ertürk - Nature methods, 2024 - nature.com
To comprehensively understand tissue and organism physiology and pathophysiology, it is
essential to create complete three-dimensional (3D) cellular maps. These maps require …

Metasurfaces for Quantitative Biosciences of Molecules, Cells, and Tissues: Sensing and Diagnostics

A Barulin, DD Nguyen, Y Kim, C Ko, I Kim - ACS Photonics, 2024 - ACS Publications
Metasurfaces have revolutionized optical biosensing and diagnostic assays due to their
sensitivity, compactness, and label-free operation. However, metasurface applications in …

Enablers and challenges of spatial omics, a melting pot of technologies

T Alexandrov, J Saez‐Rodriguez… - Molecular Systems …, 2023 - embopress.org
Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of
publications presenting novel methods for obtaining spatially resolved information for any …

Multiplex protein imaging in tumour biology

N de Souza, S Zhao, B Bodenmiller - Nature Reviews Cancer, 2024 - nature.com
Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Spatial transcriptomic technologies

TY Chen, L You, JAU Hardillo, MP Chien - Cells, 2023 - mdpi.com
Spatial transcriptomic technologies enable measurement of expression levels of genes
systematically throughout tissue space, deepening our understanding of cellular …

Seeing plants as never before

L Borisjuk, P Horn, K Chapman, PM Jakob… - New …, 2023 - Wiley Online Library
Imaging has long supported our ability to understand the inner life of plants, their
development, and response to a dynamic environment. While optical microscopy remains …

Barcoded multiple displacement amplification for high coverage sequencing in spatial genomics

J Kim, S Kim, H Yeom, SW Song, K Shin, S Bae… - Nature …, 2023 - nature.com
Determining mutational landscapes in a spatial context is essential for understanding
genetically heterogeneous cell microniches. Current approaches, such as Multiple …