Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Key Points Cerebral Cavernous Malformations CCMs are found in approximately 0.5% of
the population and characteristically manifest with headache, seizure, or focal neurologic …

To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common
and most severe of congenital brain arteriovenous malformations, we performed an …

Molecular characterization of vascular anomalies has revealed that affected endothelial
cells (ECs) harbor gain-of-function (GOF) mutations in the gene encoding the catalytic α …

Cellular homeostasis is continuously challenged by environmental cues and cellular stress
conditions. In their defense, cells need to mount appropriate stress responses that …

Extra-axial cavernous hemangiomas (ECHs) are complex vascular lesions mainly found in
the spine and cavernous sinus. Their removal poses significant risk due to their vascularity …

Cerebral cavernous malformations (CCMs) are a neurovascular anomaly that may occur
sporadically or be inherited due to autosomal dominant mutations in KRIT1, CCM2 or …

Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …

BACKGROUND: Cerebral cavernous malformations (CCMs) are vascular malformations that
frequently cause stroke. CCMs arise due to loss of function in one of the genes that encode …

A high tumor mutation burden (TMB) is known to drive the response to immune checkpoint
inhibitors (ICI) and is associated with favorable prognoses. However, because it is a one …