The great escape; the hallmarks of resistance to antiangiogenic therapy
The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …
different agents, most of them targeting the well known vascular endothelial growth factor …
[HTML][HTML] Metabolic reprogramming in triple-negative breast cancer
Since triple-negative breast cancer (TNBC) was first defined over a decade ago, increasing
studies have focused on its genetic and molecular characteristics. Patients diagnosed with …
studies have focused on its genetic and molecular characteristics. Patients diagnosed with …
The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL
Reversal of ischemia is mediated by neo-angiogenesis requiring endothelial cell (EC) and
pericyte interactions to form stable microvascular networks. We describe an unrecognized …
pericyte interactions to form stable microvascular networks. We describe an unrecognized …
Crosstalk between the nervous system and tumor microenvironment: Functional aspects and potential therapeutic strategies
L Wang, J Ge, H Han, Y Jia, Y Qin - Cancer Letters, 2024 - Elsevier
Recent advancements in understanding the tumor microenvironment (TME) have
highlighted the critical role of the nervous system in cancer progression. This review …
highlighted the critical role of the nervous system in cancer progression. This review …
The role of glutamate receptors in the regulation of the tumor microenvironment
S Koda, J Hu, X Ju, G Sun, S Shao, RX Tang… - Frontiers in …, 2023 - frontiersin.org
Glutamate, as one of the most important carbon sources in the TCA cycle, is central in
metabolic processes that will subsequently influence tumor progression. Several factors can …
metabolic processes that will subsequently influence tumor progression. Several factors can …
NMDA-type glutamate receptor activation promotes vascular remodeling and pulmonary arterial hypertension
Background: Excessive proliferation and apoptosis resistance in pulmonary vascular cells
underlie vascular remodeling in pulmonary arterial hypertension (PAH). Specific treatments …
underlie vascular remodeling in pulmonary arterial hypertension (PAH). Specific treatments …
2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents
Y Wan, J Long, H Gao, Z Tang - European Journal of Medicinal Chemistry, 2021 - Elsevier
Cancer has been the second heath killer being next only to cardiovascular diseases in
human society. Although many efforts have been taken for cancer therapy and many …
human society. Although many efforts have been taken for cancer therapy and many …
Metabotropic glutamate receptors in cancer
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic
signaling. However, accumulating evidence suggests roles of mGluRs in human …
signaling. However, accumulating evidence suggests roles of mGluRs in human …
[HTML][HTML] The molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy
H Liu, C Li, B Cao, Y Jiang, L Han, R Xu, J Lin… - Translational …, 2022 - Elsevier
According to the 2020 data released by the International Agency for Research on Cancer,
breast cancer has surpassed lung cancer as the world's most newly diagnosed first-time …
breast cancer has surpassed lung cancer as the world's most newly diagnosed first-time …
Involvement of neuronal factors in tumor angiogenesis and the sha** of the cancer microenvironment
Emerging evidence suggests that nerves within the tumor microenvironment play a crucial
role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves …
role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves …