To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

The demand for organ transplantation and repair, coupled with a shortage of available
donors, poses an urgent clinical need for the development of innovative treatment strategies …

About 3,000 individuals in the United States are awaiting a donor heart; worldwide, 22
million individuals are living with heart failure. A bioartificial heart is a theoretical alternative …

The concept of regenerating diseased myocardium by implantation of tissue-engineered
heart muscle is intriguing, but convincing evidence is lacking that heart tissues can be …

This study was designed to develop a versatile method for fabricating complex and
heterogeneous three-dimensional (3D) tissue constructs using simultaneous ink-jetting of …

End-organ failure is one of the major healthcare challenges in the Western world. Yet, donor
organ shortage and the need for immunosuppression limit the impact of transplantation. The …

Since techniques for cardiomyocyte isolation were first developed 35years ago, experiments
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …

The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for
the past decade. Profound advances in human stem cell biology and technology, tissue …

Cardiovascular diseases (CVD) constitute a major fraction of the current major global
diseases and lead to about 30% of the deaths, ie, 17.9 million deaths per year. CVD include …

Rationale: Tissue engineering may provide advanced in vitro models for drug testing and, in
combination with recent induced pluripotent stem cell technology, disease modeling, but …