Shear stress is essential for normal physiology and malignancy. Common physiological
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …

This mini-review discusses agent-based models as modeling techniques for studying
pattern formation of multi-cellular systems in biology. We introduce and compare different …

Cell-cell junctions respond to mechanical forces by changing their organization and
function. To gain insight into the mechanochemical basis underlying junction …

Abstract The three-dimensional (3D) organization of cells determines tissue function and
integrity, and changes markedly in development and disease. Cell-based simulations have …

Embryo development requires biochemical signalling to generate patterns of cell fates and
active mechanical forces to drive tissue shape changes. However, how these processes are …

Tissue morphogenesis is driven by local cellular deformations that are powered by
contractile actomyosin networks. How localized forces are transmitted across tissues to …

Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that
regulate the exchange of signaling molecules and their receptors within tissues. However …

Chemical signalling is the primary means by which cells communicate in the embryo. The
underlying principle refers to a group of ligand-producing cells and a group of cells that …

Roots navigate through soil integrating environmental signals to orient their growth. The
Arabidopsis root is a widely used model for developmental, physiological and cell biological …

Collective cell migration is a highly complex process in which groups of cells move together.
A fundamental question is how cell ensembles can migrate efficiently. In some cases, the …