Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …

Helicases and translocases are a ubiquitous, highly diverse group of proteins that perform
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …

H2A. Z is an evolutionary conserved histone variant involved in transcriptional regulation,
antisilencing, silencing, and genome stability. The mechanism (s) by which H2A. Z regulates …

For a couple of decades the chromatin field has endured undeserved neglect. Indeed, what
could be so exciting about a monotonous repeating structure whose purpose in life was to …

In all organisms, cell proliferation is orchestrated by coordinated patterns of gene
expression. Transcription results from the activity of the RNA polymerase machinery and …

A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell
development and differentiation. They are often the targets of cancer, neurological disorders …

Recent reports reinforce the notion that nucleosomes are highly dynamic in response to the
process of transcription. Nucleosomes are displaced at promoters during gene activation in …

The integrity of DNA is continuously challenged by metabolism-derived and environmental
genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks …

Although histones can form nucleosomes on virtually any genomic sequence, DNA
sequences show considerable variability in their binding affinity. We have used DNA …

Regulation of eukaryotic gene expression is far more complex than one might have
imagined 30 years ago. However, progress towards understanding gene regulatory …