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Autoimmunity and organ damage in systemic lupus erythematosus
Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …
almost every aspect of the immune system contributes to the expression of systemic …
Regulating IRFs in IFN driven disease
The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …
roles in many aspects of the immune response, including immune cell development and …
MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1
Q Li, W Hu, Q Huang, J Yang, B Li, K Ma… - Signal transduction and …, 2023 - nature.com
Unhealable diabetic wounds need to be addressed with the help of newer, more efficacious
strategies. Exosomes combined with biomaterials for sustained delivery of therapeutic …
strategies. Exosomes combined with biomaterials for sustained delivery of therapeutic …
The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
Anti-inflammatory microRNAs and their potential for inflammatory diseases treatment
Inflammation is a complicated biological and pathophysiological cascade of responses to
infections and injuries, and inflammatory mechanisms are closely related to many diseases …
infections and injuries, and inflammatory mechanisms are closely related to many diseases …
Inhibition of toll-like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics
The recognition of invading pathogens and endogenous molecules from damaged tissues
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …
The role of epigenetics in autoimmune/inflammatory disease
Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …
and caused by the innate immune system or autoimmune and driven by adaptive immune …
Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies
to generate new data and support the advent of precision medicine (PM). Recent scientific …
to generate new data and support the advent of precision medicine (PM). Recent scientific …
MicroRNAs: history, biogenesis, and their evolving role in animal development and disease
The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries
in small RNA biology have redefined the biological landscape by significantly altering the …
in small RNA biology have redefined the biological landscape by significantly altering the …
[HTML][HTML] MicroRNAs in neuroinflammation: implications in disease pathogenesis, biomarker discovery and therapeutic applications
The central nervous system can respond to threat via the induction of an inflammatory
response. Under normal circumstances this response is tightly controlled, however …
response. Under normal circumstances this response is tightly controlled, however …