The mammalian Nrf/CNC proteins (Nrf1, Nrf2, Nrf3, p45 NF-E2) perform a wide range of
cellular protective and maintenance functions. The most thoroughly described of these …

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified
cellular housekee** are the hallmarks of improved healthspan and extended lifespan …

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …

Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …

Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …

While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …

As a central hub of cellular metabolism and signaling, the mitochondrion is a crucial
organelle whose dysfunction can cause disease and whose activity is intimately connected …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Environmental mixtures of chemicals constitute a prevalent issue in ecotoxicology and the
development of new methods to reduce the uncertainties associated with their ecological …

Advances in the field of redox biology have contributed to the understanding of the
complexity of the thiol-based system in mediating signal transduction. The redox …